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Objective:To analyze survival in patients with advanced oral cancer from prospective clinical trials. Methods:From 2008 to 2010, 256 patients with oral cancer at clinical stage III/IVA were randomly categorized into two groups. Patients in the experi-mental group received neo-adjuvant chemotherapy, surgery, and post-operative radiation, and patients in the control group underwent surgery and post-operative radiation. All patients were routinely followed-up after treatments. Survival was analyzed using Kaplan–Meier method and log-rank test, and differences were considered statistically significant at P value lower than 0.05. Results: Each group was composed of 128 patients. With the median follow-up period of 60 months, the 5-year overall survival rate was 61.7%and the disease-free survival rate was 53.9%. The overall survival rate (P=0.350) and the disease-free survival rate (P=0.160) were not sig-nificantly different between the experimental and control groups. Patients with positive pathological response to neo-adjuvant chemo-therapy exhibited significantly improved overall survival (P＜0.05). Conclusion:Radical surgery should be emphasized to improve the prognosis of oral cancer. Functional reconstruction could also improve the quality of life and survival of patients. Despite that neo-adju-vant chemotherapy could not improve the survival of patients with advanced oral cancer in entirety, it could benefit patients exhibiting positive treatment responses.
ABSTRACT
Objective To obstor.e analgesic effect of cancer pain by radiation of acupoint with HPD millimeter-wave. Methol One 100patlents with serious cancer pain were treated by HPD millmeter-wave instrument (MW group) 30 minuies each time once a day. The radiatnt heads were put on the acupoints according to channeis. 40 patients with serious cancer pain accepting drug treamtment as control groud. The patieuts were evaluated one week after the treatment. Result Pain was signficantly relieved in 27 patients(27%)and decreased in 40 cases(40%) in millimeter wave group. Total analgesic rate was 67% (67/100)in MW group. Pain was relieved in 4 cases(10%) in control group(P＜0.001) Conclusion Radiation of acupoint with millimeter-wave is a safe, effective, and prompt method for cancer pain.